MENOL PLUS

MECHANISM OF ACTION

Vitamins are essential for normal metabolic functions including hematopoiesis. The B-complex vitamins are necessary for the conversion of carbohydrate, protein, and fat into tissue and energy

METHYLCOBALAMIN

Methylcobalamin is one of the two coenzyme forms of fiber. B12. Evidence indicates this form. In addition to having a theoretical advantage over B12 cyanocobalamin, some metabolic and therapeutic applications are not shared by other types of fibers. B12. Methylcobalamin, and will highlight potential therapeutic relevance for Bell’s palsy. Cancer, diabetes, neuropathy, eye function, heart rate, variability, HIV, homocysteinemia, male-impotence, and sleep disorders.

FOLIC ACID

Folic acid works in a water-soluble vitamin in its complete reduced form (1-carbon for the synthesis of tetrahydrofolate, folate, purine, and pyrimidine, as well as the remethylation cycle of homo-cysts for methionine. Folic acid After absorption there is a complex vitamin. Gastrointestinal tract. Folic acid hectically transforms into tetrahydrofolic acid, which is covalent in the biosynthesis of purine and thymidylates of nucleic acids. An exogenous source of folic acid is essential for the maintenance of normal erythropoiesis. (Lack of thymidylate synthesis from its deficiency can result in megaloblastic and macrocytic anemia).

PYRIDOXINE HYDROCHLORIDE

Pyridoxine-dependent detects an autosomal recessive trait, resulting in defective binding of pyridoxine to its apoenzyme, glutamate decarboxylase, the apoenzyme catalyzing the conversion of glutamic acid to gamma-aminobutyric acid (GABA) as an inhibitory neuron. Serves in The seizure threshold is reduced in infants with low concentrations of GABA.

ALPHA-LIPOIC ACID

In an open-label, parallel-cohort study, pharmacokinetics, metabolism, and safety and renal function on alpha-lipoic, with 16 patients (8 with reduced renal function, 8 with an end-stage renal disease requiring hemodialysis). The effect was assessed by acid (chaotic acid) by comparing pharmacokinetic parameters with a reference group of 8 healthy subjects. Alpha-lipoic acid 600 mg was administered daily for 4 days, and pharmacokinetic parameters were measured on days 1 and 4. The average percentage of dose excreted in urine as a parent compound was 0.2 and 0.05 with healthy subjects and subjects. Decreased renal function, respectively.

ONSET OF ACTION 4 hrs. Of age.

The seizures generally stop within 2-3 min. following administration.

INDICATIONS AND USAGE

(1) Diagnosis and treatment of pyridoxine-dependent seizures.

(2)-Prevention and/or treatment of vit. B6 deficiency.

Menol-Plus is indicated for supportive nutritional supplementation in situations in which water-soluble vitamins are necessarily or medically necessary. These include Conditions due to lack of water-soluble vitamins, or low absorption or bioavailability – gastrointestinal disorders, chronic alcoholism, feudal diseases, prolonged or wasting diseases, hyperthyroidism, or poorly-controlled diabetes. Conditions resulting from increased need for water-soluble vitamins – pregnancy, severe burns, recovery from surgery.

Pharmacokinetic Properties:

Mecobalamin is the neurologically active form of vitamin B12 and is a water-soluble vitamin in the body. This enzyme is covalent in methionine synthase, which acts to move methyl groups from homocysteine ​​to the regeneration of methionine. In anemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and maturation and division of erythrocytes.

Absorption: Peak plasma concentrations after 3 hr (oral); 0.9 hr (IM); 3 min (IV).

Excretion: Via urine.

Drug-Drug interactions:

At least 5 mg of pyridoxine daily may reduce the efficacy of levodopa in the treatment of Parkinson’s. Therefore, MENOL-PLUS is not recommended for patients undergoing such therapy.

Precautions:

Some of the general conditions listed above may require additional nutritional supplementation. For example, during pregnancy, supplementation with fat-soluble vitamins and minerals may be necessary according to a person’s dietary habits. MENOL-PLUS is not intended for the treatment of severe specific deficiencies. Patient Information: Because toxic reactions have been reported by harmful use of certain vitamins, urge patients to follow your specific instructions regarding dosage.

Breastfeeding:

B12 is passed through breastmilk to the baby – but in very small amounts, and infants require 0.4 micrograms (mcg) of vitamin B12, which lasts up to 6 months, and 7–12 months. Is 0.5 mg by age.

Fertility:

Research suggests that having high levels of B-12 and folate can increase fertility in women undergoing infertility treatment.

Dosage:

The Dietary Reference Intake (DRI, also known as Recommended Daily Allowance [RDA]) for vitamin B12 is 2.4 mcg/day.

There is a paucity of clinical trials with specific dosage recommendations for methylcobalamin. The dosage is based on the recommended dosage for vitamin B12. High doses of methylcobalamin (1,500 mcg/day) have been used in limited studies.

Duration of action:

Cyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous sites of injection; The plasma level of the compound reaches its peak within 1 hour after intramuscular injection. If a person stops consuming the vitamin, it usually takes about 3 to 5 years in the body’s reserves of this vitamin.

Adverse Reaction:

Venous irritation, pain, nausea, headaches, irritability, profound sedation.

Storage:

Store at room temperature. Protect from moisture and light. Parenteral: Store at room temperature. Do not expose to direct light.

Overdosage:

Vitamin B12 is an essential vitamin. This means that the body needs vitamin B12 to function properly. Vitamin B12 can be found in foods such as meat, fish, and dairy products. It can also be made in the laboratory. It is often taken in combination with other B vitamins.

Vitamin B12 has commonly used for vitamin B12 deficiency, a condition in which the level of vitamin B12 in the blood is very low, as well as cyanide poisoning and high levels of homocysteine ​​in the blood (hyperhomysistemia).

Contraindictions:

Known hypersensitivity to Vit. B6. Menol is contraindicated in patients known to be hypersensitive to any of its components.

Warnings:

Follow all instructions on your medicine label and package. Tell all your healthcare providers about all your medical conditions, allergies, and all the medicines you use.

Pregnancy: Compatible at usual dosages.

Children:

Safety and effectiveness in pediatric patients have not been established.