NOM

Mechanism of Action

NIMESULIDE

This newer NSAID is a relatively weak inhibitor of PG synthesis and there is some evidence to indicate relative COX-2 selectivity. Anti-inflammatory action may be exerted by other mechanisms as well, eg. Reduced generation of superoxide by neutrophils, inhibition of PAF synthesis and TNFα release, free radical scavenging, inhibition of metalloproteinase activity in cartilage.

The analgesic, antipyretic and anti-inflammatory activity of nimesulide has been rated comparable to other NSAIDs.

It has been used primarily for short-lasting painful inflammatory conditions like sports injuries, sinusitis, and other ear-nose-throat disorders, dental surgery, bursitis, low backache, dysmenorrhoea, postoperative pain, osteoarthritis, and fever.

Indications:

In NOM for a variety of conditions requiring anti-inflammatory, analgesic, antipyretic activities, e.g. osteoarthritis, extra-articular rheumatic diseases, pain and inflammation after the operative intervention and following acute trauma, relief of fever and pain associated with acute respiratory tract inflammation and dysmenorrhea.

Pharmacokinetic Properties:

NOM is almost completely absorbed orally, 99% plasma protein bound, extensively metabolized, and excreted mainly in urine with a t ½ of 2-5 hours. Plasma t ½ is 2-3 hours. Effects after an oral dose last 3-5 hours

NOM does not affect platelet function or clotting factors and is not uricosuric.

Drug-Drug interactions:

When NOM is taken along with Cyclosporine, Digitalis glycosides, Lithium, Methotrexate, Phenytoin there will be elevated serum levels of these drugs and an increased chance of adverse effects.

Precautions:

Those with Alcohol abuse, Colitis, Crohn’s disease, diverticulitis, gastric ulcer, Diabetes mellitus, Hemorrhoids, Hepatitis, renal disease, rectal irritation or bleeding, Systemic lupus erythematosus, and Tobacco abuse may have an increased chance of adverse effects.

Fertility:

The use of Nimesulide 100mg Tablets/granules may impair female fertility and is not recommended in women attempting to conceive

Dosage:

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Duration of action:

Nimesulide has a relatively rapid onset of action, with meaningful reductions in pain and inflammation observed within 15 minutes from drug intake

Adverse Reaction:

In isolated antipyretic doses, NOM is safe and well-tolerated. Nausea and rashes occur occasionally, leucopenia is rare.

Adverse effects of NOM are gastrointestinal (epigastralgia, heartburn, nausea, loose motions), dermatological (rash, pruritus), and central (somnolence, dizziness).

Storage:

Protect from heat and humidity; store at <25°C.

Overdosage:

Seek emergency medical treatment or contact your doctor in case of an overdose.

Oral dosage form in adults :100 mg b.i.d In children : 5 mg/kg/day in 2 or 3 divided doses.

10-12 mg / kg every 4 to 6 hrs.

Contraindications:

NOM is contraindicated in hypersensitivity, active peptic ulcer, moderate to severe hepatic disease, and in pregnancy.

Warnings:

Prolonged use can lead to serious complications such as abdominal bleeding and kidney problems. Inform your doctor if you have a history of heart disease or stroke. Avoid consuming alcohol while taking Nimesulide 100mg Tablet as it may increase your risk of stomach problems.

Pregnancy:

Can be given- no risks are known in connection with therapeutic doses.

Breastfeeding:

Allowed in therapeutic doses for women who are breast-feeding, only small concentrations in breast milk.

Children:

Well suited