CYS D
Diclofenac Potassium (50 mg), Serratiopeptidase (10 mg)
CYS-D 50mg / 10mg Tablet is a combination of two medicines. It is used to reduce pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It is also used to relieve muscle pain, back pain, toothache, ear and throat pain.
Serratiopeptidase is a proteolytic enzyme used to reduce inflammation, has antiademic, analgesic, fibrinolytic, and caseinolytic properties. It is used to treat muscle aches, back pain, toothache, menstrual cramps, and sports injuries. It also reduces pain, swelling, and stiffness of joints due to arthritis. Reducing these symptoms helps you more in your normal daily tasks. This drug is known as an non-steroidal anti-inflammatory drug (NSAID).
Diclofenac is used to relieve pain and swelling in various mild to moderate painful conditions. It is used to treat muscle aches, back pain, toothache, menstrual cramps, and sports injuries. It also reduces pain, swelling, and stiffness of joints due to arthritis. Reducing these symptoms helps you more in your normal daily tasks.
Mechanism of Action
Diclofenac Potassium, safe and potent NSAID is used for pain relief in heart and diabetes patients. When combined with a proteolytic enzyme serratiopeptidase, pain, inflammation, and tenderness rapidly resolve.
The primary mechanism responsible for its anti-inflammatory/antipyretic/analgesic action is inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX).
Serratiopeptidase
It is a proteolytic enzyme derived from Serratia spp. Serratiopeptidase is a proven proteolytic enzyme that has direct mucolytic action, breaks down mucus and promotes expulsion, and helps in antibiotic penetration.
Pharmacodynamics
High enzymatic activity and potent anti-inflammatory effects with inhibition of prostaglandin and bradykinin hydrolysis of COX-2. It also helps in the rapid healing of trauma.
Indications
Pain and edema, Tendonitis, Dental extractions, Episiotomy, Breast engorgement, tonsillectomy, Oedema after ocular surgery, Bronchiectasis.
Half-life
1.2-2 hr (35% of the drug enters enterohepatic recirculation)
Onset of action
1-hour duration of action – 12 hours.
Pharmacokinetic Properties:
Bioavailability – 100%; Protein – more than 99% binding; Metabolism – liver, no active metabolites exist; Half-life – 1.2–2 hr (35% of the drug enters enterohepatic recurrence); Excretion – bile, only 1% in urine.
Drug-Drug interactions:
Not reported.
Precautions:
In patients with renal failure or liver failure. when taking any anti-inflammatory agent on an empty stomach, the physician should alert the patient to abdominal pain. Such enzyme preparations should be used in patients with gastritis and a history of gastric ulcers, as well as in patients taking blood thinners.
Breastfeeding:
Tell your doctor if you are breastfeeding, as there is no information available about the use of this medicine. Your doctor will tell you about the use of this medicine after assessing the benefits over the risks.
Fertility:
information not available
Dosage:
Adults-5 to 10mg tab 3 times daily. 10- 30 mg tab /day.
Duration of action:
8 to 10 hrs
Adverse Reaction:
Diclofenac is one of the better-tolerated NSAIDs. 20% of patients on long-term treatment suffered with side effects, out of which only 2% had to discontinue the drug, mostly due to gastrointestinal complaints. Contraceptive hypersensitivity against a history of diclofenac, bronchospasm, shock, rhinitis, urticaria) after the use of aspirin or another NSAID, third-trimester pregnancy.
Storage:
Store below 25 degrees Celsius, protect from light and moisture.
Overdosage:
Give supportive measures and symptomatic treatment
Contraindications:
Blood coagulation abnormalities disturbance or under treatment with anticoagulants.
Warnings:
Caution should be exercised in patients with a history of liver or kidney disease, during pregnancy and breastfeeding.
Children
Use with caution.
Pregnancy
Use with caution.
Breast-feeding
Use with caution.
Old age
Use with caution.